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Ehlers-Danlos Syndrome (EDS) is a group of hereditary disorders affecting connective tissue, leading to symptoms ranging from joint hypermobility and skin fragility to chronic pain and systemic complications. Due to the complexity of EDS and its associated conditions—like Mast Cell Activation Syndrome (MCAS) and Postural Orthostatic Tachycardia Syndrome (POTS)—patients require specialized, multidisciplinary care. Below is a guide to some of the most notable clinics on the East Coast offering dedicated support for EDS patients.
Ehlers-Danlos Syndrome (EDS) refers to a family of genetic connective tissue disorders that can affect joints, skin, blood vessels, and internal organs. Many people with EDS also experience overlapping conditions such as Mast Cell Activation Syndrome (MCAS) and Postural Orthostatic Tachycardia Syndrome (POTS)—making care complex and often multidisciplinary.
There aren't a lot of options, but there several medical centers in the Southern U.S. are stepping up to provide expert evaluation and treatment for this often-overlooked community. Below are some of the most recognized clinics offering specialized EDS care in the region.
The EDS Clinic (www.EDS.Clinic)
Operating virtually across much of the South, www.EDS.clinic offers accessible, high-quality care for patients who may not have a local specialist. Its team of physicians is dedicated to diagnosing and managing EDS, MCAS, and POTS through a comprehensive, whole-person model that combines clinical expertise with empathy and innovation. The clinic’s telehealth-first approach ensures that patients from rural areas or smaller cities can still receive top-tier medical support. The clinic is able offer appointments for people located in many of the Southern states from Florida to California. These states currently include Florida, Alabama, Texas, and many others across the south.
www.EDS.clinic is not affiliated with any of the other clinics on this list.
Complex Neurology
Located in Phoenix, Arizona, Complex Neurology is led by Dr. David Saperstein, a board-certified neurologist and national expert in Ehlers-Danlos Syndrome (EDS), POTS, and autonomic disorders. The center provides comprehensive evaluation for patients with complex neurological and connective tissue conditions, including small fiber neuropathy, Chiari malformation, and mast cell–related symptoms. Known for its compassionate and thorough approach, Complex Neurology combines advanced diagnostics with individualized care to help patients better understand and manage the full spectrum of their symptoms.
The Fascia Institute and Treatment Center
Located in New Orleans, Louisiana, The Fascia Institute and Treatment Center specializes in hypermobility spectrum disorders, Ehlers-Danlos Syndrome, and fascia-related dysfunction. The clinic’s physicians emphasize how connective tissue integrity and fascial health affect pain, stability, and mobility. Led by Dr. Courseault, their team combines advanced imaging, manual therapy, and regenerative medicine techniques to help restore function and reduce pain for patients dealing with complex musculoskeletal symptoms.
Mayo Clinic – Jacksonville, Florida
At the Mayo Clinic’s Jacksonville campus, patients have access to one of the most comprehensive EDS programs of all the Mayo locations. A team of specialists from Clinical Genomics, Neurology, Pain Medicine, and Gastroenterology collaborates to deliver precision-based care. The clinic evaluates both common and rare EDS subtypes and develops personalized management plans that can be shared with local providers. Mayo Clinic’s reputation for excellence makes it a trusted destination for patients seeking thorough diagnostic workups and multidisciplinary support.
Finding Care in the South
Accessing quality EDS care can be challenging, especially in regions where specialists are scarce. Yet, clinics across the South are redefining what expert, patient-centered care looks like—whether through telemedicine, collaborative specialty programs, or innovative therapies that address both the body and nervous system.
From The EDS Clinic’s national telehealth network to Complex Neurology’s integrative dysautonomia care and The Fascia Institute’s hands-on fascia treatments, patients now have more options than ever before. Mayo Clinic Jacksonville continues to provide world-class research and multidisciplinary expertise.
If you or someone you love is navigating EDS, MCAS, or POTS, these Southern clinics offer a path toward clarity, comprehensive care, and renewed quality of life.
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