The Best MCAS Specialists in the USA by state

Mast Cell Activation Syndrome (MCAS) is a complex condition that requires specialized care from knowledgeable physicians familiar with mast cell disorders, connective tissue diseases, and related conditions such as Ehlers-Danlos Syndrome (EDS) and dysautonomia. Finding an experienced MCAS specialist can be challenging; therefore, we've compiled a state-by-state guide to some of the best clinicians in the U.S. who focus on MCAS treatment. This list includes leading experts in MCAS diagnosis and treatment. Many of these MCAS specialists work at The EDS Clinic, but those who do not are indicated by an asterisk (*).

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The Best MCAS Specialists by State

California

• Carolyn Martinez, MSN, RN, FNP (The EDS Clinic)
• Brittany Goss, DO (The EDS Clinic)
• Cindy Xi, MD* (USC*)

Texas

• Dr. Jim Harris, MD (The EDS Clinic)

Minnesota

• Dr. Andrea Joplin, MD (The EDS Clinic)

Alabama

• Dr. Sujana Reddy, DO (The EDS Clinic)

Rhode Island

• Dr. Pradeep Chopra, MD (Center for Complex Conditions*)

Illinois

• Dr. Jim Harris, MD (The EDS Clinic)

Ohio

• Dr. Jim Harris, MD (The EDS Clinic)

North Carolina

• Dr. Jim Harris, MD (The EDS Clinic)

Michigan

• Dr. Jim Harris, MD (The EDS Clinic)

New Jersey

• Dr. Jim Harris, MD (The EDS Clinic)

Washington

• Dr. Jenny Zhang, MD (The EDS Clinic)‍
• Dr. Jim Harris, MD (The EDS Clinic)

New York

• Dr. Larry Afrin, MD (AIM Center for Personalized Medicine*)
• Dr. Tania Dempsey, MD (AIM Center for Personalized Medicine*)

Arizona

• Dr. David Saperstein, MD (Center for Complex Neurology, EDS & POTS*)

Indiana

• Dr. Jim Harris, MD (The EDS Clinic)

Wisconsin

• Dr. Jim Harris, MD (The EDS Clinic)

Colorado

• Dr. Jim Harris, MD (The EDS Clinic)

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*Providers and clinics noted with an asterisk are not affiliated with www.EDS.clinic

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Meet the Experts: Leading MCAS Specialists in the U.S.

Dr. Jim Harris, MD – Medical Director, The EDS Clinic

Dr. Jim Harris is the Medical Director of The EDS Clinic, specializing in MCAS, Ehlers-Danlos Syndrome (EDS), and Postural Orthostatic Tachycardia Syndrome (POTS). He is board-certified in Allergy & Immunology and has conducted nearly 300 research studies, including trials involving Xolair, an important MCAS therapeutic. Dr. Harris is widely recognized for his work in diagnosing and managing complex multisystem disorders.​

Dr. Andrea Joplin, MD – EDS and MCAS Specialist, The EDS Clinic

Dr. Andrea Joplin brings 25 years of clinical experience and a wealth of expertise to The EDS Clinic. Her personal experience with hypermobile Ehlers-Danlos syndrome (hEDS) provides her with a unique perspective and deep-seated dedication to serving people affected by EDS. Dr. Joplin earned her medical degree from the University of Minnesota, where she also completed a residency in ophthalmology. She serves on the Medical Board of the Connective Tissue Coalition, an organization dedicated to promoting connective tissue disease research, advocacy, and education among healthcare providers.

Dr. Sujana Reddy, DO – Chronic Illness Specialist, The EDS Clinic

Dr. Sujana Reddy is a compassionate physician whose personal health journey profoundly influences her medical practice. Diagnosed with Ehlers-Danlos Syndrome (EDS) at 28, she has firsthand experience with chronic illness complexities. Her battle with long-term effects of COVID-19 further deepened her insight into such conditions. Dr. Reddy earned her Doctor of Osteopathic Medicine degree from the Alabama College of Osteopathic Medicine in 2021 and completed her Internal Medicine training at East Alabama Health in 2024. She actively serves on the board of Awareness For Potsies, advocating for individuals with Postural Orthostatic Tachycardia Syndrome (POTS). Her experiences have made her a dedicated advocate for patient empowerment and understanding.

Carolyn Martinez, MSN, RN, FNP – Nurse Practitioner, The EDS Clinic

Carolyn Martinez, FNP brings over 15 years of experience as a family nurse practitioner, with expertise in urgent care, primary care, and cardiology. Fluent in English and Spanish, she has dedicated her career to serving underserved communities across California and New Mexico. Over the past six years, Carolyn has focused on supporting the EDS community and related conditions such as POTS, Mast Cell Activation Syndrome (MCAS), gastrointestinal dysmotility disorders, and chronic pain. She completed EDS ECHO training through The Ehlers-Danlos Society and has been instrumental in diagnosing and treating numerous individuals with EDS. Carolyn earned her Master of Science in Nursing from the University of California, San Francisco, and a Bachelor of Arts in Public Health from Johns Hopkins University, where she was inducted into Phi Beta Kappa. Known for her empathetic approach, she ensures patients feel seen, heard, and supported as they navigate complex medical conditions.

Dr. Pradeep Chopra, MD – Director, Center for Complex Conditions*

Dr. Pradeep Chopra* is a Harvard-trained pain medicine specialist with over 25 years of experience treating complex chronic pain and multisystem disorders. He is board-certified in both Pain Medicine and Anesthesiology and serves as an Assistant Clinical Professor at Brown University’s Warren Alpert Medical School. Dr. Chopra is the Director of the Center for Complex Conditions, where he specializes in Ehlers-Danlos Syndrome (EDS), Complex Regional Pain Syndrome (CRPS), and Mast Cell Activation Syndrome.
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Dr. Brittany Goss, DO – Board Certified Rheumatologist, The EDS Clinic

Dr. Brittany Goss, DO, FACOI, FACR, is a highly experienced rheumatologist and internal medicine physician with over 16 years of expertise in diagnosing and managing complex connective tissue disorders and other rheumatological conditions. She is passionate about improving the care and quality of life for patients with hypermobility disorders, Ehlers-Danlos syndrome (EDS), and their associated comorbidities, including Mast Cell Activation Syndrome (MCAS), Postural Orthostatic Tachycardia Syndrome (POTS), and other forms of dysautonomia. Dr. Goss earned her Doctor of Osteopathy degree from the Lake Erie College of Osteopathic Medicine and completed her internal medicine residency and rheumatology fellowship at Largo Medical Center, where she served as Chief Rheumatology Fellow. She is board-certified in both rheumatology and internal medicine and holds the Fellow of the American College of Osteopathic Internists (FACOI) and Fellow of the American College of Rheumatology (FACR) designations.

Dr. Jenny Zhang, MD – EDS and MCAS Specialist, The EDS Clinic

Dr. Jenny Zhang offers more than a decade of extensive clinical experience, encompassing specialized training in both general surgery and anesthesiology. Her personal journey with hypermobile Ehlers-Danlos syndrome (hEDS) has profoundly shaped her career and aspirations, fueling her dedication to delivering exceptional care and advocacy for the EDS and hypermobile community. Dr. Zhang received her medical degree from the Louisiana State University Health Sciences Center in New Orleans and currently resides in Seattle. She is also a classically-trained chef with a dedicated interest in the concept of "food as medicine," utilizing culinary medicine to enhance the management of chronic illnesses and overall quality of life.

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